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But as any functional practitioner knows, its rarely that simple

Bloating shows up quickly as stomach tightness or fullness after meals, while weight gain develops gradually and affects the body more broadly

Recommendations for athletes on GLP-1s Still, experts in the field believe there is enough concern not just to warrant further research but to advise athletes to take steps to avoid this loss in lean body mass as much as possible

Further research may enhance our understanding of the mechanisms by which the combination of GLP-1RAs and SGLT2is acts to derive a cardiovascular benefit

This may lead to impairment of cellular signaling mechanisms and accumulation of misfolded proteins causing proteotoxicity associated with cardiac dysfunction (136143)

These findings support the continued use of GLP-1 RAs in clinical practice, but further research is needed to fully understand their long-term oncological safety, particularly in relation to non-gastrointestinal cancers and rare malignancies such as pancreatic cancer